Refrigeration, cryopreservation and pathogen inactivation: an updated perspective on platelet storage conditions
نویسندگان
چکیده
منابع مشابه
An Overview on Platelet-derived Microparticles in Platelet Concentrates: blood collection, method preparation and storage
Preparations of platelet concentrates (PCs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (PMPs) with high coagulant activity that may change platelet efficacy and safety issues. High shear stress could cause shedding of PMPs from the platelet plasma membrane, platelet aggregation, and activation of the co...
متن کاملBacterial contamination of platelet concentrates: pathogen detection and inactivation methods
Whereas the reduction of transfusion related viral transmission has been a priority during the last decade, bacterial infection transmitted by transfusion still remains associated to a high morbidity and mortality, and constitutes the most frequent infectious risk of transfusion. This problem especially concerns platelet concentrates because of their favorable bacterial growth conditions. This ...
متن کاملEffects of Liquid Storage and Cryopreservation on Platelet Surface Glycoproteins, Light Scatter, and Procoagulant Activity
This study was designed to examine the effects of standard 22°C platelet storage and platelet cryopreservation ;pn surface glycoproteins, light scattering properties and surface-bound factor V using flow cytometry. Single donor platelet units were collected in ACD (formula A) using a^Haemonetics Mobile Collection System. The units were either liquid-preserved at 22°C with rotation for up to 7 d...
متن کاملEconomics of pathogen inactivation technology for platelet concentrates in Japan.
Residual risk of transmitting recognized and emerging blood-borne pathogens via blood transfusion in Japan persists despite advances in blood safety screening. The INTERCEPT Blood System (IBS) for platelets was developed to inactivate a broad spectrum of pathogens to reduce the risk of transfusion-transmitted infections. In this study we assessed the economic impact of the IBS on platelet trans...
متن کاملan overview on platelet-derived microparticles in platelet concentrates: blood collection, method preparation and storage
preparations of platelet concentrates (pcs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (pmps) with high coagulant activity that may change platelet efficacy and safety issues. high shear stress could cause shedding of pmps from the platelet plasma membrane, platelet aggregation, and activation of the co...
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ژورنال
عنوان ژورنال: Vox Sanguinis
سال: 2018
ISSN: 0042-9007
DOI: 10.1111/vox.12640